In recent years, nucleic acid therapy involving various types of ribonucleic acids (RNAs), including messenger RNA (mRNA), small interfering RNA (siRNA), and microRNA (miRNA), has rapidly emerged as a newRead More
Author: alexbrown
PEG cGMP Manufacture: From Material Preparation to Quality Control
PEG manufacturing (Polyethylene Glycol) involves several steps and processes. Here is a general outline of how to conduct PEG manufacturing in a cGMP (current Good Manufacturing Practices) compliant facility: Raw materialRead More
Bioconjugation Strategies for Enhancing Drug Delivery and Therapeutic Efficacy
In recent years, bioconjugation has emerged as a powerful strategy for improving drug delivery and enhancing therapeutic efficacy. By linking drugs to various biological entities, such as proteins, antibodies, nanoparticles,Read More
ADC Cleavable Linker: Classification and Mechanism of Action
Antibody-drug conjugates (ADCs), as emerging anticancer drugs, can deliver highly cytotoxic molecules directly to cancer cells to kill them. ADC is a monoclonal antibody covalently bound to cytotoxic chemical substancesRead More
Fermentation Production of ADC Payloads
Targeted therapies have significantly advanced the field of cancer therapy, and among these, antibody-drug conjugates (ADCs) have emerged as a viable therapeutic strategy. ADCs increase efficacy and decrease systemic toxicityRead More